Mount Sinai School of Medicine (Siemens)

The dataset includes diffusion and structural data from 6 monkeys.

Usage Agreement

Creative Commons – Attribution-NonCommercial Share Alike (CC-BY-NC-SA)- Standard INDI data sharing policy. Prohibits use of the data for commercial purposes.

Species

Macaca mulatta

Scan Procedures and Parameters

Animals were anesthetized with isoflurane (2.5%) and monitored for depth of anesthesia

Sample Description

• Sample size: 6
• Age distribution: 5.3-6.3 years
• Weight distribution: 7.70-11.00 kg
• Sex distribution: all male

Click here for the full sample description (.csv)

Phenotypic Assessments

The monkeys received multiple scans during behavioral training. The additional data will be part of a future release, post-publication)

Scan Procedures and Parameters

Ethics approval: Icahn School of Medicine at Mount Sinai (ISMMS) IACUC

Animal care and housing: ISMMS is staffed with veterinarians with non-human primate expertise and a staff of skilled veterinary and husbandry technicians. Monkeys were housed in a group of 6 indoors in standard primate caging, in housing rooms containing other monkeys. The single-housed monkey was the last in her group and had failed repeated attempts to find compatible cage mates from elsewhere in the colony. All monkeys received environmental enrichment consisting of toys and novel food items.

Any applicable training: All males received cognitive tests via touch screen apparatus

Scanning preparations

Anesthesia procedures: Anesthesia procedures: ketamine, meloxicam, buprenorphine prior to intubation and placement in stereotaxic frame; isoflurane maintenance anesthesia (1-2% to effect).

Time between anesthesia and scanning: Monkeys were placed in the scanner as soon as isoflurane anesthesia was initiated and stable

Head fixation: Monkeys were placed in an MRI-compatible stereotaxic frame (Crist)

Position in scanner and procedure used: Sphinx position head first (recorded as head first supine in scanner; note that header info have been corrected to reflect anatomy). Fiducial marker placed on left side.

Contrast agent: none

During scanning

Physiological monitoring: pulse rate, SpO₂, end tidal CO₂, inspired/expired isoflurane, blood pressure

Additional procedures: Artificial ventilation was used to maintain end-tidal CO₂ in a normocapnic range wherever possible, to avoid effects of hypercapnia on the BOLD signal. Normothermia maintained by heated air blanket

Scan sequences

• Scanner type: Siemens Skyra 3T
• Head coil: 4-channel clamshell coil
• Optimization of the magnetic field prior to data acquisition: Manual shimming
• Resting-state: Scans were acquired and will be uploaded in a future release


• Diffusion-weighted:
• Voxel resolution: 1.0 x 1.0 x 1.0 mm
• TE: 95ms
• TR: 5000ms
• Slice gap: 0mm
• b-value: 1000s/mm²
• 68 directions (3 averages; reverse polarity images included
• Structural:
  • MPRAGE
  • Voxel resolution: 0.5 x 0.5 x 0.5 mm
  • TE: 2.11ms
  • TR: 4000ms
  • TI: 650/1820ms
  • Flip angle: 8° (3 averages)
  • T1
  • Voxel resolution: 0.5 x 0.5 x 0.5 mm
  • TE: 3.02ms
  • TR: 2700ms
  • TI: 800ms
  • Flip angle: 7°
  • T2
  • Voxel resolution: 0.5 x 0.5 x 0.5 mm
  • TE: 539ms
  • TR: 3200ms

Publications

• Simon, Damatac et al. in preparation

Personnel

• Paula L. Croxson, DPhil¹
• Christienne G. Damatac²
• Jamie Nagy¹

¹Department of Neuroscience, Mount Sinai School of Medicine, New York, NY
²Donders Institute for Brain, Cognition and Behavior, Netherlands

Acknowledgements

We thank Lazar Fleysher, Rafael O’Halloran, Prantik Kundu, Junqian Xu, Ronald Primm, Ignacio Medel, Pedro Hernandez, Carlos Rodriguez, Crystal Johnson, and Zahi Fayad for their support.

Funding

This data repository was supported by the Icahn School of Medicine at Mount Sinai.

Downloads

Click here to download the data. Users will first be prompted to log on to NITRC and will need to register with the 1000 Functional Connectomes Project website on NITRC to gain access to the PRIME-DE datasets.